Involvement of cyclic AMP and prostaglandins in morphine analgesia, tolerance and physical dependence.
نویسنده
چکیده
منابع مشابه
The role of ATP-dependent K+ channels in antinociception, tolerance and morphine dependence
Tolerance and dependence are two main problems that have limited morphine administration as an analgesic drug and they might be as a result of changes in the number and affinity of receptors, dysfunction of adenylate cyclase, impaired coupling between activated µ receptor and K+ channels, and changes in the K+ and Ca2+ channels. There are several reports concerning the role of some of these...
متن کاملThe effect of alloxan-induced diabetes on anti-nociception and on the development of morphine tolerance and dependence in rats
Diabetes is one of the most common diseases in all societies including Iran. One of its important complications is the neuropathic pain, which can be relieved by opioid drugs such as morphine. Opioid therapy is restricted due to development of tolerance and physical or mental dependence. In this study, the effect of diabetes on morphine analgesia and development of morphine tolerance and depend...
متن کاملThe effect of alloxan-induced diabetes on anti-nociception and on the development of morphine tolerance and dependence in rats
Diabetes is one of the most common diseases in all societies including Iran. One of its important complications is the neuropathic pain, which can be relieved by opioid drugs such as morphine. Opioid therapy is restricted due to development of tolerance and physical or mental dependence. In this study, the effect of diabetes on morphine analgesia and development of morphine tolerance and depend...
متن کاملOverexpression of type 7 adenylyl cyclase in the mouse brain enhances acute and chronic actions of morphine.
The mechanisms by which morphine-induced analgesia and tolerance and physical dependence on morphine arise have been the subject of intense study, and much work has pointed to the involvement of cAMP-mediated events in the neuroadaptive phenomena leading to morphine tolerance and/or dependence. We overexpressed an opioid receptor-stimulatable form of adenylyl cyclase (type 7) in the central ner...
متن کاملSwim stress decrease the development of morphine tolerance apart from nitric oxide inhibition
Stress and chronic pain have been shown to prevent the development of tolerance to morphine analgesia, which appears to be related to neuroendocrine activity and alternation in neurochemicals. Also the involvement of nitric oxide (NO) has been implicated in tolerance to morphine analgesia. In our pervious study, we showed that co-administration of swim stress (ss) with chronic morphine, prevent...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 22 4 شماره
صفحات -
تاریخ انتشار 1978